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| Date of Trade | Team 1 | Player/s | Player/s | Team 2 |
| 2 Feb 2004 |  Reds | JD Drew Tim Spooneybarger 2004 2nd-round Draft Pick (#31 overall) 2005 2nd-round Draft Pick (#25 overall) | Ben Broussard Mark Ellis 2004 1st-round Draft Pick (#17 overall) 2004 2nd-round Draft Pick (#37 overall) | Padres 
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| 4 May 2004 |  Rockies | Mike DeJean Mark Redman Carlos Zambrano 2005 2nd-round Draft Pick (#37 overall) | Matt Clement Ugueth Urbina 2005 3rd-round Draft Pick (#44 overall) | Giants 
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| 28 May 2004 |  Cubs | Jim Mecir Bernie Williams | Rocco Baldelli 2005 3rd-round Draft Pick (#55 overall) | Mariners 
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| 11 June 2004 |  Angels | Ryan Dempster Alex Gonzalez 2005 3rd-round Draft Pick (#49 overall) | José Contreras | Twins 
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| 1 April 2005 | Giants | Moved to  Boston
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| 2 April 2005 | Angels | Jermaine Dye Aaron Rowand | Oliver Perez Jason Philips | Braves 
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| 8 April 2005 |  Rangers | Ryan Klesko Kevin Millwood Scott Schoeneweis Todd Zeile 2005 2nd-round Draft Pick (#34 overall) | Raúl Ibañez José Vidro 2005 1st-round Draft Pick (#13 overall) | Indians 
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| 15 April 2005 | Mariners | Kevin Brown 2005 2nd-round Draft Pick (#35 overall) 2006 2nd-round Draft Pick | Edgar Martinez | Diamondbacks 
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| 1 May 2005 |  Royals | Freddy Garcia JC Romero | Áramis Ramirez | Padres
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| 1 May 2005 | Reds | Derek Jeter | Sean Casey | Padres
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| 1 May 2005 | Reds | Aubrey Huff Toby Hall | Iván Rodriguez Marco Scutaro | Royals
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| 3 May 2005 | Reds | Adam LaRoche Roy Oswalt Todd Williams | Tony Armas Darrel May Travis Hafner Edgar Rentería | Dodgers 
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Multi-Party Trades
| Date of Trade | From | Player | To |
| Angels | 2005 2nd-round Draft Pick (#29 overall) | Mariners
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| Royals | Kevin Brown | Mariners
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| Rangers | Miguel Cairo | Angels
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| 28 Jan 2004 | Rangers | Roger Cedeno | Royals
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| Rangers | Ben Sheets | Mariners
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| Mariners | LaTroy Hawkins | Royals
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| Mariners | Kevin Millwood | Rangers
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| Angels | Marlon Anderson | Braves
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| Angels | Aquilino Lopez Jarrod Washburn | Cubs
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| Braves | Bobby Abreu | Angels
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| Braves | Sidney Ponson | Cubs
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| 28 Mar 2004 | Braves | Chone Figgins 2005 2nd-round Draft Pick (#30 overall) | Mariners
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| Cubs | Brandon Webb | Angels
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| Cubs | Brian Anderson Jason Phillips | Braves
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| Cubs | Todd Hollandsworth Brian Shouse | Mariners
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| Mariners | Jay Payton | Braves
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| Braves | Mark Hendrickson | Diamondbacks
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| Braves | Octavio Dotel | Rangers
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| Diamondbacks | Dan Wright | Braves
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| 17 Apr 2004 | Diamondbacks | Mike Bacsik | Rangers
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| Rangers | Gary Knotts 2005 3rd-round Draft Pick (#54 overall) | Braves
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| Rangers | Kiko Calero Mike Stanton | Diamondbacks
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| Angels | Jim Mecir Bernie Williams | Cubs
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| Angels | Todd Zeile Player to be named later | Rangers
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| 27 May 2004 | Cubs | Corey Patterson Juan Rivera | Angels
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| Cubs | Adrian Beltre | Rangers
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| Rangers | Giovanni Carrara Choi Hee Seop | Angels
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| Rangers | Tony Batista | Cubs
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 Athletics | Melvin Mora | Braves
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| Athletics | José Valverde | Cubs
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| 11 May 2005 | Braves | Jorge Sosa | Cubs
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| Cubs | Crístian Gúzman Shane Spencer | Athletics
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